CEACAM ELISA Kits
CEACAM (Carcinoembryonic Antigen-related Cell Adhesion Molecule) ELISA kits are immunoassays designed for the quantitative measurement of CEACAM proteins in biological samples such as serum, plasma, and cell culture supernatants. CEACAMs are part of the immunoglobulin superfamily and play significant roles in cell adhesion, signal transduction, and immune regulation. They are important in research related to cancer, infectious diseases, and immune response regulation. CEACAM1 and CEACAM5 (CEA, Carcinoembryonic Antigen) are commonly targeted in these assays due to their relevance in cancer diagnostics and tumor progression studies.
Content of CEACAM ELISA Kits: CEACAM ELISA kits typically include:
- Recombinant CEACAM protein standards for generating a calibration curve.
- Detection antibodies conjugated to an enzyme such as HRP (Horseradish Peroxidase) for colorimetric detection.
- Substrate solution (e.g., TMB – 3,3',5,5'-Tetramethylbenzidine) for signal development.
- Stop solution to terminate the enzymatic reaction.
- Sample and assay diluents, wash buffers, and assay buffers.
- Detailed instructions for assay execution and sample preparation.
Application of CEACAM ELISA Kits: CEACAM ELISA kits are used in various research and clinical applications, including:
- Cancer research: Quantifying CEACAM levels, particularly CEACAM5 (CEA), as it is a well-known tumor marker for colorectal, lung, pancreatic, and other cancers. Elevated levels can assist in monitoring tumor progression, response to therapy, and recurrence.
- Immune response regulation: Analyzing CEACAMs' function in modulating immune cell interactions, especially in studies focusing on T cells and neutrophils.
- Clinical diagnostics: Measuring CEA levels as part of routine testing for cancer diagnosis and monitoring in patients.
- Cell adhesion and signaling research: Exploring CEACAMs' involvement in cell-cell adhesion, intracellular signaling, and how they affect cellular communication and response.
- Pharmaceutical research: Evaluating the impact of potential therapeutic agents targeting CEACAM pathways, which could be relevant in cancer treatment and immunotherapy development.
CEACAM ELISA kits are essential tools for cancer research, immunology studies, and clinical diagnostics, providing sensitive and specific measurements that contribute to understanding and managing various diseases.
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