CLIC ELISA Kits

CLIC ELISA Kits are specialized immunoassays developed for the quantitative measurement of Chloride Intracellular Channel (CLIC) family proteins in biological samples. CLIC proteins, including CLIC1, CLIC2, CLIC3, and others, are unique chloride channels involved in various cellular processes, such as ion transport, oxidative stress response, and cell cycle regulation. Abnormal CLIC expression is associated with several diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders.

Components of CLIC ELISA Kit

• Pre-coated Microplate: Microplate wells pre-coated with antibodies specific to a target CLIC protein, enabling selective capture from samples.
• Detection Antibodies: Enzyme-linked detection antibodies (often HRP-conjugated) specific to the CLIC protein, generating a signal proportional to the target protein concentration.
• Stop Solution: Terminates the enzymatic reaction for consistent endpoint measurement.
• Wash Buffer and Sample Diluent: Optimized buffers to reduce background noise and nonspecific binding, ensuring specific and accurate results.

Applications of CLIC ELISA Kits

• Cardiovascular Disease Research: CLIC proteins are associated with vascular function and response to oxidative stress. Measuring CLIC levels helps in understanding their role in cardiovascular diseases, such as atherosclerosis and hypertension.
• Inflammation and Immune Response: CLIC proteins are implicated in inflammatory processes. Researchers can use CLIC ELISA Kits to quantify these proteins in models of inflammation, providing insights into immune regulation and inflammatory disease mechanisms.
• Biomarker Discovery: CLIC proteins have potential as biomarkers for various diseases. The CLIC ELISA Kit supports research on CLIC levels as possible diagnostic or prognostic markers, especially in oncology and neurodegeneration.

CLIC ELISA Kits offer a robust, sensitive solution for studying CLIC protein levels in various biological contexts. They are essential tools in cancer, neurodegenerative disease, and cardiovascular research, enabling precise measurement of CLIC proteins to advance our understanding of cellular signaling, disease progression, and potential therapeutic targets.