DNM ELISA Kits

Dynamins (DNMs) are a family of GTPase enzymes essential for membrane remodeling processes, including endocytosis, vesicle trafficking, and mitochondrial fission. The primary isoforms—Dynamin-1 (DNM1), Dynamin-2 (DNM2), and Dynamin-3 (DNM3)—are differentially expressed across tissues and play distinct roles in cellular functions. Accurate quantification of these proteins is crucial for understanding their involvement in various physiological and pathological processes.

Key Features:

• Sensitivity and Specificity: Designed to detect low concentrations of specific dynamin isoforms with high specificity, minimizing cross-reactivity with other proteins.
• Assay Range: Typically, these kits offer a detection range suitable for physiological and pathological levels of dynamin proteins. For example, the Mouse DNM1 ELISA Kit from FineTest has a detection range of 39.063–2500 pg/mL with a sensitivity of 23.438 pg/mL. Fn Test
• Sample Types: Validated for use with various sample matrices, including serum, plasma, tissue homogenates, and cell culture supernatants, providing versatility for different research needs.
• Assay Time: The total assay duration varies but generally ranges from 2 to 4 hours, facilitating efficient processing of multiple samples.

Applications:

• Neuroscience Research: DNM1 is predominantly expressed in neurons and is involved in synaptic vesicle recycling. Measuring its levels is essential in studies related to synaptic function and neurological disorders.
• Cell Biology Studies: DNM2 is ubiquitously expressed and plays a role in clathrin-mediated endocytosis and cytokinesis. Quantifying DNM2 can aid in understanding cellular processes such as membrane trafficking and cell division.
• Disease Biomarker Research: Alterations in dynamin expression or function have been implicated in various diseases, including neurodegenerative disorders and cancer. Dynamin ELISA kits are utilized to study these associations and explore potential therapeutic targets.

By providing accurate quantification of dynamin proteins, these ELISA kits are invaluable tools in cell biology, neuroscience, and disease research, facilitating studies on membrane dynamics, synaptic function, and the role of dynamins in health and disease.