FGL ELISA Kits

The FGL ELISA Kit is a specialized immunoassay designed for the quantitative measurement of Fibrinogen-Like Protein 1 (FGL1) in biological samples. FGL1, also known as Hepassocin, is a liver-derived protein with significant roles in immune regulation, liver regeneration, and cell proliferation. FGL1 has garnered attention as a potential immune checkpoint molecule due to its interaction with LAG-3 (Lymphocyte-Activation Gene 3), an inhibitory receptor on immune cells. 

Content of FGL ELISA Kit

A typical FGL ELISA Kit includes:

• Pre-coated Microplate: Microplate wells pre-coated with high-specificity antibodies targeting FGL1, allowing for selective capture from the sample.
• Detection Antibodies: Enzyme-linked detection antibodies (often HRP-conjugated) specific to FGL1, facilitating a measurable colorimetric or luminescent signal.
• Standards and Controls: Calibrated FGL1 standards for creating a standard curve, along with positive and negative controls to ensure assay accuracy and reproducibility.
• Substrate Solution: Chromogenic or chemiluminescent substrate that reacts with the enzyme to produce a signal proportional to FGL1 concentration.

Application of FGL ELISA Kit

The FGL ELISA Kit has broad applications in immunology, oncology, and liver disease research:

• Cancer Immunology and Immune Checkpoint Research: FGL1 acts as an immune checkpoint ligand by binding to LAG-3, inhibiting T-cell function and helping tumors evade immune detection. Measuring FGL1 levels with the FGL ELISA Kit supports studies on tumor immunology and the development of cancer immunotherapies targeting the LAG-3/FGL1 axis.
• Biomarker Development: FGL1 is a promising biomarker for certain cancers and liver conditions. The FGL ELISA Kit is used in biomarker research, allowing researchers to correlate FGL1 levels with disease progression, prognosis, or treatment response.
• Drug Screening and Therapeutic Development: As FGL1 is a potential therapeutic target, particularly in cancer and immune modulation, the FGL ELISA Kit supports drug screening and development by assessing the impact of potential drugs on FGL1 levels or activity.

The FGL ELISA Kit is a valuable tool for advancing research in cancer immunotherapy, liver biology, and inflammatory diseases, offering accurate and sensitive quantification of FGL1 to support understanding and therapeutic development related to these conditions.