MSP ELISA Kits

The MSP ELISA Kit is a specialized immunoassay designed for the quantitative measurement of Macrophage-Stimulating Protein (MSP), also known as hepatocyte growth factor-like protein (HGFL), in biological samples. MSP is a plasma protein involved in various cellular processes, including cell migration, proliferation, and survival. It primarily functions through its receptor, RON (Recepteur d’Origine Nantais), which is expressed on macrophages and epithelial cells. 

Content of MSP ELISA Kit

A standard MSP ELISA Kit typically includes:

• Pre-coated Microplate: Microplate wells pre-coated with antibodies specific to MSP, ensuring specific and high-affinity binding from samples.
• Detection Antibodies: Enzyme-linked detection antibodies (usually HRP-conjugated) specific to MSP for generating a quantifiable signal.
• Standards and Controls: Calibrated MSP standards for creating a standard curve, along with positive and negative controls to validate the accuracy and reliability of the assay.
• Substrate Solution: Chromogenic or chemiluminescent substrate that reacts with the enzyme to produce a detectable signal proportional to MSP concentration.

Application of MSP ELISA Kit

The MSP ELISA Kit has diverse applications in research related to inflammation, tissue repair, cancer, and cellular signaling:

• Cancer Research: MSP and its receptor RON are involved in cancer cell migration, invasion, and resistance to apoptosis, especially in cancers such as breast, lung, and pancreatic cancer. The MSP ELISA Kit helps quantify MSP levels in tumor samples, aiding studies on cancer progression and potential therapeutic targeting.
• Fibrosis Research: Elevated MSP levels have been linked to fibrotic processes in organs such as the liver and lungs. MSP ELISA Kits are useful in studying fibrosis and the signaling pathways involved in extracellular matrix deposition and tissue remodeling.
• Therapeutic Development: Since MSP is implicated in various diseases, it is a target of interest in therapeutic research. The MSP ELISA Kit can aid in drug screening and testing, helping evaluate compounds that may modulate MSP activity or its receptor RON.

The MSP ELISA Kit is a valuable tool in studies of cell signaling, inflammation, cancer, and tissue regeneration, providing precise and sensitive quantification of MSP to support advancements in understanding these processes and developing new therapeutic approaches.