mTOR ELISA Kits
The mTOR ELISA Kit is a specialized immunoassay developed for the quantitative measurement of mammalian target of rapamycin (mTOR) levels in biological samples. mTOR is a central protein kinase in the mTOR signaling pathway, which regulates cell growth, proliferation, metabolism, and survival in response to environmental cues, such as nutrient availability, energy levels, and growth factors. Aberrant mTOR signaling is associated with various diseases, including cancer, metabolic disorders, and neurodegenerative diseases.
Content of mTOR ELISA Kit
A standard mTOR ELISA Kit includes:
- Pre-coated Microplate: Microplate wells pre-coated with high-specificity antibodies targeting mTOR, ensuring selective and accurate capture from samples.
- Detection Antibodies: Enzyme-linked detection antibodies (typically HRP-conjugated) specific to mTOR, enabling quantifiable signal generation.
- Standards and Controls: Calibrated mTOR standards for constructing a reliable standard curve and positive/negative controls to validate assay accuracy.
- Substrate Solution: Chromogenic or chemiluminescent substrate that reacts with the enzyme to produce a measurable signal proportional to mTOR concentration.
Application of mTOR ELISA Kit
The mTOR ELISA Kit has broad applications in cancer research, metabolic studies, and neurological research:
- Neurodegenerative Disease Research: Dysregulated mTOR signaling is linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Measuring mTOR levels supports studies on neurodegeneration, autophagy, and cellular stress, providing insights into potential therapeutic targets.
- Aging and Longevity Studies: mTOR is associated with aging and cellular senescence. The mTOR ELISA Kit is useful in aging research, enabling studies on how modulating mTOR activity might extend lifespan or improve health during aging.
- Drug Development and Screening: As mTOR is a therapeutic target, particularly in cancer and metabolic diseases, the ELISA Kit supports drug screening by measuring the effect of candidate compounds on mTOR activity, aiding in therapeutic development.
The mTOR ELISA Kit is a valuable tool for research into cell signaling, cancer biology, metabolic health, and aging, offering precise and sensitive quantification of mTOR to support advancements in understanding and treating diseases associated with mTOR dysregulation.
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