NEFH ELISA Kits

Neurofilament Heavy Polypeptide (NEFH), also known as neurofilament heavy chain (NF-H), is a critical component of the neuronal cytoskeleton, playing a pivotal role in maintaining neuronal caliber and axonal integrity. Elevated levels of NEFH in biological fluids are indicative of neuronal damage and have been associated with various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer's disease.

Key Features:

• Sensitivity and Specificity: Designed to detect low concentrations of NEFH with high specificity, minimizing cross-reactivity with similar proteins.
• Assay Range: Typically, these kits offer a detection range suitable for physiological and pathological levels of NEFH. For example, the Human NEFH ELISA Kit from Assay Genie has a detection range of 3.12–200 pg/mL with a sensitivity of 0.78 pg/mL. Assay Genie
• Sample Types: Validated for use with various sample matrices, including serum, plasma, cerebrospinal fluid (CSF), tissue homogenates, and cell culture supernatants, providing versatility for different research needs.
• Assay Time: The total assay duration varies but generally ranges from 1 to 5 hours, facilitating efficient processing of multiple samples.

Applications:

• Neurodegenerative Disease Research: NEFH is a biomarker for neuronal damage. Measuring its levels is essential in studies related to neurodegenerative diseases such as ALS, MS, and Alzheimer's disease. Elevated NEFH levels in CSF and blood correlate with disease progression and severity.
• Clinical Diagnostics: NEFH ELISA kits are used in clinical settings to assess neuronal injury, aiding in the diagnosis and monitoring of neurodegenerative conditions. They provide a non-invasive means to evaluate disease progression and response to therapy.
• Drug Development: In pharmacological research, NEFH levels serve as biomarkers to evaluate the efficacy of neuroprotective agents. Monitoring NEFH can help determine the impact of therapeutic interventions aimed at reducing neuronal damage.

By providing accurate quantification of NEFH levels, these ELISA kits are invaluable tools in neuroscience research and clinical diagnostics, facilitating studies on neuronal damage, neurodegenerative diseases, and the efficacy of therapeutic interventions.