SERPINC ELISA Kits

The SERPINC ELISA Kit is a specialized immunoassay developed for the quantitative detection of SERPINC1, also known as antithrombin III (ATIII), in various biological samples. SERPINC1 is a critical serine protease inhibitor involved in the regulation of blood coagulation, where it inhibits thrombin and other enzymes in the coagulation cascade. Mutations or deficiencies in SERPINC1 are associated with thrombotic disorders, making it an important biomarker for conditions such as deep vein thrombosis, pulmonary embolism, and other coagulopathies.

Content of SERPINC ELISA Kit

A typical SERPINC ELISA Kit includes:

• Standards and Controls: Calibrated standards for constructing a reliable standard curve and control samples for quality control and assay validation.
• Substrate Solution: Chromogenic or chemiluminescent substrate to produce a detectable signal proportional to the SERPINC1 concentration.
• Stop Solution: Stops the enzymatic reaction, ensuring accurate endpoint measurement.
• Wash Buffer and Diluent: Buffers for optimal assay conditions, minimizing nonspecific binding and enhancing specificity.

These components are tailored to enable sensitive and precise quantification of SERPINC1 in various sample types, including plasma, serum, and cell lysates.

Application of SERPINC ELISA Kit

The SERPINC ELISA Kit has significant applications in thrombosis research, coagulation studies, and clinical diagnostics:

• Hematological Disorder Diagnostics: In clinical diagnostics, the SERPINC ELISA Kit can be used to assess antithrombin deficiency as part of the workup for hereditary or acquired thrombophilia, aiding in risk stratification for thrombotic events.
• Drug Efficacy Testing in Anticoagulation Therapy: Monitoring SERPINC1 levels can be valuable in evaluating the efficacy of anticoagulant drugs, particularly those that interact with the antithrombin pathway, such as heparin, whose activity depends on sufficient SERPINC1 levels.
• Biomarker Research: SERPINC1 levels may serve as a biomarker for evaluating coagulation status in various pathological states, supporting efforts to establish clinical correlations between antithrombin levels and disease severity or progression.

The SERPINC ELISA Kit is an essential tool in coagulation research and diagnostics, providing precise measurements of SERPINC1 levels to support studies in hematology, cardiovascular health, and therapeutic monitoring.