SIGLEC ELISA Kits
Siglec (Sialic acid-binding immunoglobulin-type lectins) are a family of cell surface proteins predominantly expressed on immune cells, which play essential roles in immune regulation by binding sialylated glycans on cellular surfaces. Siglecs mediate cell-cell interactions, modulate immune response, and contribute to self-tolerance. Given their implications in immune modulation and association with autoimmune diseases, infections, and cancers, Siglec proteins are critical targets for immunological research and therapeutic development.
Content and Application of Siglec ELISA Kits
Siglec ELISA Kits are specifically designed to detect and quantify various Siglec proteins in biological samples, including serum, plasma, and cell culture supernatants. Each kit employs highly sensitive antibodies that selectively bind to Siglec antigens, allowing for the precise detection of these proteins at picogram to nanogram levels. These kits generally use a sandwich ELISA format, where a capture antibody immobilizes the Siglec protein on a solid surface, followed by a detection antibody for signal generation. The reaction is measured colorimetrically or via luminescence, yielding quantitative data on Siglec levels.
Applications in Research and Clinical Diagnostics
- Immuno-oncology Research: Siglec ELISA kits support studies on Siglec-15 and other Siglecs that play roles in cancer immunotherapy. These proteins are involved in immune escape mechanisms used by tumors, and precise quantification of Siglecs in patient samples can provide insights into tumor immune evasion strategies.
- Autoimmune and Inflammatory Disease Research: Changes in Siglec expression are linked to autoimmune diseases like lupus and rheumatoid arthritis. By measuring Siglec proteins, researchers can assess immune dysregulation patterns, paving the way for diagnostic biomarkers and therapeutic interventions.
- Infectious Disease Studies: Since Siglecs are involved in pathogen recognition, particularly through sialic acid interactions, they are key markers for studying host-pathogen interactions. Siglec ELISA kits enable profiling of immune responses in conditions such as bacterial and viral infections, providing data on immune activation and suppression.
These Siglec ELISA Kits offer robust tools for applications ranging from basic research to translational studies, supporting advancements in immunotherapy, infectious disease understanding, and autoimmune disease management.
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