PSMB ELISA Kits

The Proteasome Subunit Beta (PSMB) ELISA Kits are specialized immunoassay tools designed for the quantitative detection and analysis of PSMB proteins, specifically the beta subunits of the proteasome complex. Proteasomes are multicatalytic proteinase complexes responsible for degrading unneeded or damaged proteins by proteolysis, a highly regulated, ATP-dependent process. PSMB proteins, part of the proteasomal beta subunit family, are integral in immunoproteasomes and the formation of antigenic peptides for MHC class I presentation. 

Content:

The PSMB ELISA kits include high-sensitivity antibodies that specifically bind to the PSMB targets (such as PSMB5, PSMB7, or other subunits) and are calibrated to detect low concentrations of these proteins in biological samples. Each kit generally comprises pre-coated plates, detection antibodies, calibration standards, and substrates, which together provide a streamlined process for accurately quantifying PSMB protein levels. Due to their specificity and sensitivity, these kits are ideal for detecting PSMB in cell lysates, serum, plasma, or tissue homogenates. 

Applications:

PSMB ELISA kits are widely used in biomedical research, particularly for studying the ubiquitin-proteasome pathway's role in diseases. Key applications include:

• Cancer Research: Due to the proteasome's role in protein degradation, changes in PSMB levels are studied in cancers where dysregulated proteasome activity may contribute to tumor growth and survival. PSMB ELISA kits assist in assessing proteasome inhibitors' efficacy in targeting cancer cells.
• Immunology and Autoimmune Disorders: Immunoproteasomes, which include PSMB subunits, are central to generating peptide antigens for immune surveillance. Thus, these kits are used in studying autoimmune diseases where aberrant immune responses may result from altered antigen processing.
• Infection and Inflammation: PSMB ELISA kits are also valuable in infectious disease research for evaluating immune responses to infections, as immune cells rely on the proteasome for generating peptide antigens.

The PSMB ELISA kits offer reliable, quantitative data essential for understanding the proteasome's role in these processes and their involvement in pathophysiology, making them indispensable in translational and clinical research.